| 来氟米特联合糖皮质激素治疗类风湿性关节炎相关肾损害43例临床分析 |
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| 引用本文： | 梁灼源,韦锋,冯明亮,石晓峰.来氟米特联合糖皮质激素治疗类风湿性关节炎相关肾损害43例临床分析[J].医疗保健器具,2011,18(4):532-534. |
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| 作者姓名： | 梁灼源 韦锋 冯明亮 石晓峰 |
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| 作者单位： | 广东省江门市中心医院肾内科,广东江门,529000 |
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| 摘 要： | 目的研究来氟米特（LEF）治疗风湿性关节炎相关肾损害的疗效和安全性。方法排除药物等继发因素,经临床及肾活检确诊与类风湿性关节炎本身相关的肾损害患者43例,随机分为实验组24例（来氟米特＋糖皮质激素）和对照组19例（糖皮质激素）。观察治疗12周后两组相关生化指标、疗效和不良反应,并进行评价。结果治疗12周后实验组、对照组疗效比较：实验组完全缓解8例（33.33%）,显效4例（16.67%）,有效5例（20.83%）,无效7例（29.17%）,总有效17例（70.83%）;对照组完全缓解2例（10.53%）,显效4例（21.05%）,有效3例（15.79%）,无效10例（52.63%）,总有效9例（47.37%）。实验组与对照组比较,总有效率有显著性差异（P〈0.05）。结论来氟米特联合糖皮质激素治疗类风湿性关节炎相关肾损害近期降尿蛋白疗效显著,肾功能稳定,具有较好的耐受性及安全性。
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| 关 键 词： | 来氟米特 类风湿性关节炎 IgA肾病 膜性肾病 |
Clinical Analysis of 43 Cases of Renal Damage Associated with Rheumatoid Arthritis Treated with Leflunomide Combined with Glucocorticoids |
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| LIANG Zhuoyuan,WEI Feng,FENG Mingliang,SHI Xiaofeng.Clinical Analysis of 43 Cases of Renal Damage Associated with Rheumatoid Arthritis Treated with Leflunomide Combined with Glucocorticoids[J].Medicine Healthcare Apparatus,2011,18(4):532-534. |
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| Authors: | LIANG Zhuoyuan WEI Feng FENG Mingliang SHI Xiaofeng |
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| Institution: | LIANG Zhuoyuan,WEI Feng,FENG Mingliang,SHI Xiaofeng(Department of Nephrology,Jiangmen Central Hospital,Jiangmen 529000,China) |
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| Abstract: | Objective To observe the effects of LEF on the renal damage associated with rheumatoid arthritis.Methods 43 patients of renal damage associated with rheumatoid arthritis were recruited for analysis.24 cases were treated with LEF and Pred(treatment group),while 19 cases were just treated with Pred(control group).The clincial effects and side effects were evaluated after treatment for 12 weeks.Results Compared with the control group's remission rate(47.37% remission rate),the treatment group(70.83% remission ... |
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| Keywords: | Leflunomide Rheumatoid arthritis IgA nephropathy Membranous nephropathy |
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