sFasL检测对结核性与恶性胸腔积液鉴别诊断价值的探讨

目的探讨sFasL对恶性胸腔积液与结核性胸腔积液鉴别诊断价值。方法应用ELISA法分别检测32例恶性胸腔积液和43例结核性胸腔积液中sFasL的含量,对结果进行统计学处理。结果结核性胸腔积液组sFasL(13.56±5.38 ng/ml)显著高于恶性胸腔积液组(5.72±2.59 ng/ml),二者具显著性差异(P＜0.001)。以10 ng/ml为临界值,胸腔积液中sFasL>10 ng/ml诊断为结核性胸腔积液的敏感性为81.4%(35/43),特异性为81.3%(26/32),临床诊断符合率为81.4%(61/75)。结论sFasL对结核性、恶性胸腔积液的鉴别诊断有临床实用价值。

Diagnostic values and clinical significance of detecting soluble FasL of pleural effusions in differentiating tuberculous and malignant pleural effusions

Objective To explore the diagnostic values and clinical significance of detecting soluble FasL of pleural effusions in differentiating tuberculous and malignant pleural effusions.Methods Using enzyme-linked immunosorbent assay(ELISA) method to detect the soluble FasL in 43 tuberculous pleural effusions and 32 malignant pleural effusions.Results The mean of soluble FasL of tuberculous pleural effussions(13.56±5.38ng/ml)was markedly higher than that of malignant pleural effusions(5.72±2.59ng/ml)(P＜0.001).If 10ng/ml of soluble FasL was regarded as cutoff value,the sensitivity,the specificity and accordance of diagnosing tuberculous pleural effusions were 81.4%,81.3% and 81.4%,respectively.Conclusion Soluble FasL might be a effective laboratory marks of differentiating tuberculous and malignant pleural effusions.