|
|||||
|
|
| 妊娠合并重症新型甲型H1N1流感患者抗H1N1抗体IgG亚类的分布 | |
| 引用本文： | 秦晓松,郑锐,李杨,吴丽娜,王珺,刘勇.妊娠合并重症新型甲型H1N1流感患者抗H1N1抗体IgG亚类的分布[J].中华医院感染学杂志,2011,21(10):2022-2024. |
| 作者姓名： | 秦晓松 郑锐 李杨 吴丽娜 王珺 刘勇 |
| 作者单位： | 1. 中国医科大学附属盛京医院检验科,辽宁沈阳,110004 2. 中国医科大学附属盛京医院呼吸内科,辽宁沈阳,110004 3. 中国医科大学附属盛京医院产科,辽宁沈阳,110004 |
| 摘 要： | 目的探讨妊娠合并重症甲型H1N1流感患者抗H1N1抗体各IgG亚类在血清中的分布特点。方法收集2009年11月14日-12月31日,确诊的女性甲型H1N1流感患者,分为妊娠病例组,非妊娠病例组,同时收集抗甲型H1N1抗体阳性的健康妊娠女性作为妊娠对照组,采用ELISA法检测各组血清特异性IgG及亚类的百分结合率。结果妊娠病例组的IgG2I、gG3I、gG4亚类的百分结合率中位数分别为53.0%、65.0%、61.6%,均低于妊娠对照组,差异有统计学意义(P<0.05);各组的特异性抗甲型H1N1 IgG均以IgG1亚类为主,为>70.0%,妊娠病例组的IgG2亚类占5.0%,低于非妊娠病例组的10.0%和妊娠对照组的8.0%,(P<0.05)。结论妊娠合并甲型H1N1流感患者中,特异性抗甲型H1N1 IgG以IgG1亚类为主,IgG2亚类的绝对及相对下降与甲型H1N1感染相关。 |
| 关 键 词： | 流感病毒 甲型H1N1流感 妊娠 IgG亚类 |
Distribution of IgG subclasses of anti-H1N1 antibodies in severe new influenza A (H1N1) in pregnant women |
|
| QIN Xiao-song,ZHENG Rui,LI Yang,WU Li-na,WANG Jun,LIU Yong.Distribution of IgG subclasses of anti-H1N1 antibodies in severe new influenza A (H1N1) in pregnant women[J].Chinese Journal of Nosocomiology,2011,21(10):2022-2024. | |
| Authors: | QIN Xiao-song ZHENG Rui LI Yang WU Li-na WANG Jun LIU Yong |
| Institution: | QIN Xiao-song,ZHENG Rui,LI Yang,WU Li-na,WANG Jun,LIU Yong(Shengjing Hospital of China Medical University,Shenyang,Liaoning 110004,China) |
| Abstract: | OBJECTIVE To study the distribution of IgG subclasses of anti-H1N1 antibodies in severe new influenza A(H1N1) in pregnant women.METHODS The female patient diagnosed as H1N1 virus infections from Nov 14 to Dec 31,2009 were divided to pregnant patients group and non-pregnant patients group.Another group of healthy pregnant female who had a positive anti-H1N1 IgG served as a control group.Serum enzyme-linked immunosorbnent assay(ELISA)was performed to examine the combining percentage and constitution ratio of ... |
| Keywords: | Influenza virus Influenza A(H1N1) Pregnancy IgG subclasses |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |