肠杆菌科细菌对3种碳青霉烯类药物的耐药性分析

目的研究3种碳青霉烯类抗菌药物对临床常见肠杆菌科细菌的体外抗菌活性,为碳青霉烯类抗菌药物用于治疗肠杆菌科细菌引起的临床感染提供依据。方法采用VITEK-32型全自动微生物分析系统进行菌株鉴定和药敏试验;对临床分离并鉴定的400株肠杆菌科细菌采用纸片扩散法(K-B法)进行厄他培南的药敏试验,用WHONET5.3软件对细菌耐药率进行统计分析。结果大肠埃希菌、肺炎克雷伯菌、奇异变形菌、阴沟肠杆菌、产气肠杆菌、褪色沙雷菌对厄他培南的敏感率分别为96.0%、60.0%、92.0%、95.0%、93.0%、93.0%;对亚胺培南敏感率分别为92.0%、74.0%、92.0%、97.5%、86.7%、100.0%;美罗培南分别为96.0%、78.0%、96.0%、95.0%、70.0%、93.3%。结论碳青霉烯类抗菌药物对肠杆菌科细菌有很好的治疗作用;但某些菌株已有较高的耐药性发生,临床应重视对碳青霉烯类耐药菌株的检测,以减缓耐药性的快速增长。

Drug resistance of enterobacteriaceae isolates to three carbapenem antibiotics

OBJECTIVE To investigate in vitro antibacterial activity of three carbopenem antibiotics to clinical isolates of Enterobacteriaceae and provide bases for treatment of clinical infections caused by Enterobacteriaceae strains with carbopenem antibiotics.METHODS Strains were identified and antibiotic susceptibility were determined with VITEK32 automatic bacteria identification system.Disk diffusion tests(Kirby-Bauer tests) were performed to detect the susceptibility of ertapenem against 400 clinical isolates o...