| 146株链球菌属临床感染特征及耐药性分析 |
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| 引用本文： | 吴洪巧,纪明宇,裴凤艳,汪运山.146株链球菌属临床感染特征及耐药性分析[J].中华医院感染学杂志,2011,21(12):2607-2609. |
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| 作者姓名： | 吴洪巧 纪明宇 裴凤艳 汪运山 |
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| 作者单位： | 1. 山东大学附属济南市中心医院医院感染管理科,山东,济南,250013
2. 山东大学附属济南市中心医院医院医学实验诊断中心,山东,济南,250013 |
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| 摘 要： | 目的分析医院2009年1月-2010年12月临床分离的链球菌属构成比和对常用抗菌药物的耐药性。方法采用E试验法检测肺炎链球菌对青霉素MIC,其他抗菌药物采用纸片扩散法进行药敏试验;根据CLSI2009年M100-S19判定耐药性。结果 2009年1月-2010年12月,医院临床样本中共分离出链球菌属146株,包括肺炎链球菌102株、β-溶血链球菌43株,其中酿脓链球菌(A群)14株、无乳链球菌(B群)11株,星座链球菌(G群)18株,其他链球菌1株;标本分布以呼吸道标本最多,其次为分泌物;青霉素不敏感肺炎链球菌(PISP+PRSP)的分离率为3.9%(非脑脊液标本),β-溶血链球菌对青霉素、头孢噻肟类的药物敏感率100.0%,可作为经验用药的首选药;链球菌属草绿色群,对于红霉素及克林霉素敏感性较低,均<20.0%,对于头孢吡肟耐药率达33.3%;未发现对万古霉素和利奈唑胺耐药菌株。结论医院链球菌属以肺炎链球菌和β-溶血链球菌为主,这些菌株对阿奇霉素、红霉素、克林霉素耐药现象严重,青霉素中介的肺炎链球菌增多,应及早进行检测并采取有效预防和控制措施,防止医院感染发生和暴发。
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| 关 键 词： | 药敏试验 耐药性监测 肺炎链球菌 β-溶血链球 |
Clinical characteristics of infections caused by 146 strains of streptococci and analysis of drug resistance |
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| WU Hong-qiao,JI Ming-yu,PEI Feng-yan,WANG Yun-shan.Clinical characteristics of infections caused by 146 strains of streptococci and analysis of drug resistance[J].Chinese Journal of Nosocomiology,2011,21(12):2607-2609. |
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| Authors: | WU Hong-qiao JI Ming-yu PEI Feng-yan WANG Yun-shan |
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| Institution: | WU Hong-qiao,JI Ming-yu,PEI Feng-yan,WANG Yun-shan(Jinan Central Hospital Affiliated to Shandong University,Jinan,Shandong 250013,China) |
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| Abstract: | OBJECTIVE To investigate the distribution and antibiotic resistance of streptococcus isolated from Jinan central hospital from Jan 2009 to Dec 2010.METHODS The minimum inhibitory concentrations(MICs) of penicillin for S.pneumoniae were determined by E-test.Other antimicrobial susceptibility was tested by Kirby-Bauer method.Drug resistance was judged according to the Clinical and Laboratory Standards Institute(CLSI) 2009 M100-S19.RESULTS A total of 146 strains of Streptococcus were isolated during two years,... |
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