基层医院临床分离的大肠埃希菌耐药性探讨

目的探讨山区县级医院临床分离的大肠埃希菌(ECO)的耐药现状,为临床医师抗感染用药提供试验依据。方法 155株大肠埃希菌分离培养、鉴定按照《全国临床检验操作规程》,采用常规方法进行;采用CLSI推荐的K-B法进行药敏试验和判读结果。结果医院大肠埃希菌在呼吸道、泌尿道、伤口分泌物中分离率较高,分别为59.4%、21.9%、9.7%;药敏试验结果表明,ECO对亚胺培南和美罗培南100.0%敏感,对阿米卡星、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、头孢他啶、头孢西丁耐药率较低,均<28.0%,对其余常用抗菌药物耐药率较高,均>30.0%。结论医院应采取切实有效的干预措施,关注医院感染高危人群,关注好发部位,预防与控制耐药细菌引起的医院感染暴发流行。

Investigation into antimicrobial resistance in clinical isolates of escherichia coli in grass-root hospitals

OBJECTIVE To investigate the antimicrobial resistance status of Escherichia coli(ECO) in montane county hospitals and provide the experimental evidence for clinical use of antibiotics.METHODS Referring to National Guide to Clincal Laboratory Procedures,155 ECO were isolated,cultured and identified by the routine methods.The drug susceptibility testing was performed by K-B methods recommended by CLSI.The susceptibility testing results were assessed.RESULTS ECO were mostly isolated from the respiratory tract(...