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PEA3 activates CXCL12 transcription in MCF-7 breast cancer cells |
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| Authors: | CHEN Li CHEN Bo-bin LI Jun-jie JIN Wei SHAO Zhi-min |
| Affiliation: | 1. Department of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China 2. Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040,China |
| Abstract: | Objective To explore the activity of PEA3 (polyomavirus enhancer activator 3 ) on CXCL12 (Chemokine CXC motif ligand 12) transcription and to reveal the role of PEA3 involved in CXCL12-mediated metastasis and angiogenesis in breast cancer. Methods Methods such as cell transfection, ChIP assay (chromatin immunoprecipitation), and siRNA (small interfering RNA) were applied to demonstrate and confirm the interaction between PEA3 and CXCL12. Results Over-expression of PEA3 could increase the CXCL12 mRNA level a... |
| Keywords: | polyomavirus enhancer activator 3 (PEA3) chemokine CXC motif ligand 12 (CXCL12)promoter transcription regulation |
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