超短波对肠易激综合征患者免疫功能的影响

目的　检测肠易激综合征 (IBS)患者外周血淋巴细胞数及T 淋巴细胞亚群比例 ,研究其与IBS发病机制之间的关系 ,并探讨超短波对IBS腹泻型患者免疫功能的影响。方法　采用SF 3 0 0 0全血细胞分析仪和流式细胞仪 ,分别测定 5 0例健康对照者和 65例IBS患者的淋巴细胞总数和T 淋巴细胞亚群的比例 ,并对其中 45例腹泻型IBS患者超短波治疗前、后的T 淋巴细胞亚群比例进行比较分析。结果　与健康对照组测定结果比较 ,IBS患者外周血淋巴细胞总数无明显改变 ,CD3 +水平下降 ,但差异无显著性 (P >0 .0 5 ) ,CD4+显著降低 (P <0 .0 1) ,CD8+显著升高 (P <0 .0 1) ,致CD4/CD8比值下降 (P <0 .0 1)。超短波治疗前、后T亚群测定结果有显著变化 (P <0 .0 1)。结论　IBS患者外周血淋巴细胞总数正常 ,而T淋巴细胞亚群比例失衡 ,提示IBS的发病机制可能与免疫有关 ;超短波可以改善IBS腹泻型患者机体免疫功能 ;T亚群比例的测定可用于判断腹泻型IBS患者的病情和疗效

Effect of ultrashort wave on the immune function of patients with irritable bowel syndrome

Objective To study the changes of the ratio of the T lymphocytes subgroups in the peripheral blood, and the effect of ultrashort wave diathermy on the immune function of patients with irritable bowel syndrome(IBS) Methods The SF 3000 hemocyte analysis system and the flow cytometer (FCM) were used to test the peripheral blood lymphocytes count and the T lymphocytes subgroups of 65 patients with IBS and 30 healthy subjects. And compared the ratio of the T lymphocytes subgroups of 45 patients with diarrhea type IBS after ultrashort wave therapy with the ratio before ultrashort wave therapy. Results As shown by comparison with the control group,there were no significant change in total count of peripheral blood lymphocytes in patients with IBS;the level of CD3 + lymphocyte was lower, but there were no statistically significant difference( P >0.05). The blood CD4 + lymphocyte count in patients with IBS was decreased ( P <0.01), but the blood CD8 + was increased ( P <0.01). As a result,the ratio of the CD4/CD8 was significantly decreased ( P <0.01). There was evident change ( P <0.01) after ultrashort wave therapy. Conclusion The results of this study indicated that IBS might be associated with abnormalimmunity. Ultrashort wave therapy could improve immune function of the patient.