Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats |
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Authors: | Thaís Montenegro de Andrade Ademar Soares de Melo Rui Guilherme Cardoso Dias Everton Luís Pompeu Varela Fábio Rodrigues de Oliveira José Luís Fernandes Vieira Marcieni Ataíde de Andrade Ana Cristina Baetas Marta Chagas Monteiro Cristiane do Socorro Ferraz Maia |
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Institution: | 1. Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, Instituto de Ciências da Saúde, Rua Augusto Corrêa, N°01, 66075–900 Belém, Pará, Brazil;2. Faculdade de Farmácia, Instituto de Ciências da Saude, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil |
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Abstract: | Ethnopharmacological relevancePetiveria alliacea (Phytolaccaceae) is a perennial shrub indigenous to the Amazon Rainforest and tropical areas of Central and South America, the Caribbean, and sub-Saharan Africa. In folk medicine, Petiveria alliacea has a broad range of therapeutic properties; however, it is also associated with toxic effects.Aim of the studyThe present study evaluated the putative effects of Petiveria alliacea on the central nervous system, including locomotor activity, anxiety, depression-like behavior, and memory, and oxidative stress.Materials and methodsTwo-month-old male and female Wistar rats (n=7–10 rats/group) were administered with 900 mg/kg of hydroalcoholic extracts of Petiveria alliacea L. The behavioral assays included open-field, forced swimming, and elevated T-maze tests. The oxidative stress levels were measured in rat blood samples after behavioral assays and methemoglobin levels were measured in vitro.ResultsConsistent with previous reports, Petiveria alliacea increased locomotor activity. It also exerted previously unreported anxiolytic and antidepressant effects in behavioral tests. In the oxidative stress assays, the Petiveria alliacea extract decreased Trolox equivalent antioxidant capacity levels and increased methemoglobin levels, which was related to the toxic effects.ConclusionsThe Petiveria alliacea extract exerted motor stimulatory and anxiolytic effects in the OF test, antidepressant effects in the FS test, and elicited memory improvement in ETM. Furthermore, the Petiveria alliacea extract also exerted pro-oxidant effects in vitro and in vivo, inhibiting the antioxidant status and increasing MetHb levels in human plasma, respectively. |
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Keywords: | Petiveria alliacea Anxiety Memory Depression Methemoglobin |
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