Microbial conversion of anthracyclinones to carminomycins by a blocked mutant of Actinomadura roseoviolacea |
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| Authors: | M Nakagawa Y Hayakawa K Imamura H Seto N Otake |
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| Affiliation: | Institute of Applied Microbiology, University of Tokyo, Japan. |
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| Abstract: | New anthracycline antibiotics, 1-hydroxy-11-deoxycarminomycin II and 11-deoxycarminomycin II were produced by a blocked mutant MuW1 of Actinomadura roseoviolacea from epsilon-pyrromycinone and aklavinone, respectively. We found that the enzyme catalyzing hydroxylation at the C-11 position was not lost but was down regulated in the strain MuW1. |
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