Endoscopic resection of ampullary tumors: 12-year review of 21 cases |
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Authors: | Jaume Boix Vicente Lorenzo-Zúñiga Vicente Moreno de Vega Eugeni Domènech Miquel Angel Gassull |
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Institution: | (1) Endoscopy Unit, Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916 Badalona, Barcelona, Spain |
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Abstract: | Background Endoscopic snare papillectomy is increasingly performed with curative intent for benign papillary tumors. This study aimed
to evaluate the outcome of endoscopic resection for ampullary tumors at a single center.
Methods All ampullary tumors without macroscopic features of malignancy identified by the endoscopic retrograde cholangiopancreatography
(ERCP) from January 1995 to February 2007 were included in the study. Papillectomy was performed by snare resection using
electrocautery. Argon plasma coagulation was effective for fulguration of small tissue remnants not amenable to snare resection.
Results Of the 21 patients (9 men and 12 women; mean age, 67.2 ± 14.3 years) evaluated, 11 had adenoma (7 had low-grade dysplasia
LGD] and 4 had high-grade dysplasia HGD]), and 10 had carcinoma. All the patients underwent papillectomy. Of the 21 patients,
18 had extraductal growth or minimal intraductal growth, and 3 had extensive intraductal growth. The endoscopic complications
(23.8%) included one case of mild bleeding, two cases of mild pancreatitis, and two cases of moderate pancreatitis. After
papillectomy, 15 patients underwent Whipple procedures (endoscopic failure, 74.1%), including 3 patients with extensive intraductal
growth (complete removal of the lesion impossible), 9 patients with carcinoma beyond the mucosal layer, and 3 patients with
recurrence treated surgically. Endoscopic success (28.5%) was obtained for the remaining six patients (4 with LGD and 2 with
HGD). Papillectomy was determined to be curative after a mean follow-up period of 15.9 ± 14.9 months.
Conclusions In the hands of an experienced endoscopist, endoscopic papillectomy is a clinically effective treatment for ampullary tumors
without invasive neoplasia. Evaluation of a prepapillectomy tumor extension is an important criterion for assessment of endoscopic
success. |
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Keywords: | Ampullary tumors Endoscopic resection Endoscopic snare papillectomy |
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