美托洛尔和咪哒普利对急性心肌梗死大鼠心室重构和血浆脑钠素影响的比较

目的:比较美托洛尔和咪哒普利对大鼠急性心肌梗死后心室重构和血浆脑钠素水平(BNP)的影响 及其发生时间。方法:建立大鼠心肌梗死模型,应用美托洛尔和咪哒普利治疗,分别观察1和4周,测定血浆BNP 水平和心室重构指标(相对心室重量、相对左室重量、相对右室重量、右/左室重量、左房直径、左室收缩末期内径、 左室舒张末期内径)。结果:在急性实验中,与模型对照组相比,美托洛尔未能改善心室重构,但显著地降低了血 浆BNP(P<0.05);与美托洛尔相比,咪哒普利不仅进一步降低了血浆BNP水平(P<0.01),并且显著改善了 心室重构。在慢性实验中,与模型对照组相比,美托洛尔和咪哒普利均显著改善了心室重构并降低了血浆BNP 水平(P<0.01),两组间差异无统计学意义。结论:美托洛尔和咪哒普利治疗1和4周均可降低心肌梗死大鼠血 浆BNP;咪哒普利在治疗1和4周时均可显著改善心肌梗死大鼠的心室重构,而美托洛尔仅在治疗4周时改善了 心室重构。

Influence of metoprolol and imidapril on the cardiac remodeling and plasma BNP in acute myocardial infarction rat

Objective: To investigate how and when will metoprolol and imidapril influence the cardiac remodeling and plasma BNP in acute myocardial infarction (AMI) rat. Method:AMI rats were administrated with metoprolol and imidapril after the operation for 1 or 4 weeks, respectively. Index of cardiac remodeling (RVW, RLVW, RRVW, R/LVW, LAD, LVESd, LVEDd) and plasma BNP were determined. Result:In acute experiment, compared with the control group, metoprolol didn't improve the index of cardiac remodeling, but it significantly limited the increment of plasma BNP(P< 0.05); Compared with metoprolol, imidapril significantly improved the index of cardiac remodeling and limited the increment of plasma BNP(P< 0.01). In chronic experiment, compared with the control group, both metoprolol and imidapril significantly improved the index of cardiac remodeling and limited the increment of plasma BNP(P< 0.01); There was no significant difference between the two treatment groups. Conclusion:Metoprolol and imidapril can limit the increment of plasma BNP in AMI rat. After 1 or 4 weeks' treament, imidapril can improve the AMI rat's cardiac remodeling definitely. But metoprolol can only improve the cardiac remodeling after 4 weeks' treatment.