| 阿立哌唑与利培酮治疗精神分裂症对照研究 |
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| 引用本文： | 谢根生,赵新蕾,钱国平,吴玉红,胡庆芬.阿立哌唑与利培酮治疗精神分裂症对照研究[J].中国预防医学杂志,2010(2):190-192. |
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| 作者姓名： | 谢根生 赵新蕾 钱国平 吴玉红 胡庆芬 |
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| 作者单位： | 桐庐县第二人民医院;桐庐县精神卫生中心; |
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| 摘 要： | 目的探讨阿立哌唑与利培酮对精神分裂症的疗效及安全性。方法选取80例精神分裂症患者,随机分为阿立哌唑组40例,利培酮组40例;分别给予阿立哌唑和利培酮治疗,疗程8周。在治疗前及治疗第1,2,4,6,8周末分别采用阳性和阴性症状量表（PANSS）,治疗中出现的副反应采用症状量表（TESS）对两组进行评定。并于治疗前、中、后检查催乳素水平。结果两组治疗后PANSS评分均有显著下降。阿立哌唑组的锥体外系不良反应、体质量增加及月经失调均较利培酮组少而轻,且对催乳素水平没有影响。结论本研究结果表明,两药对精神分裂症均有较好疗效,起效快,不良反应小。
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| 关 键 词： | 阿立哌唑 利培酮 精神分裂症 锥体外系 催乳素 |
A comparative study of efficacy between aripiprazole and risperidone in schizophrenia treatment |
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| XIE Gen-sheng,ZHAO Xin-lei,QIAN Guo-ping,WU Yu-hong,HU Qing-fen.A comparative study of efficacy between aripiprazole and risperidone in schizophrenia treatment[J].China Preventive Medicine,2010(2):190-192. |
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| Authors: | XIE Gen-sheng ZHAO Xin-lei QIAN Guo-ping WU Yu-hong HU Qing-fen |
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| Institution: | XIE Gen-sheng,ZHAO Xin-lei,QIAN Guo-ping,WU Yu-hong,HU Qing-fen.The Second Hospital of Tonglu County,Tonglu,Zhejiang 311519,China |
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| Abstract: | Objective To investigate the clinical efficacy and safety of aripiprazole and risperidone in treatment of the patients with acute schizophrenia.Methods Eighty patients of schizophrenia were randomly assigned into aripiprazole(n=40)and risperidone treatment groups(n=40)respectively for 8 weeks.Positive and negative syndrome scale(PANSS)and treatment emergent symptoms scale(TESS)were used before and at the end of 1,2,4,6 and 8 weeks of treatment for both groups.The plasma prolactin concentration was measured ... |
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| Keywords: | Aripiprazole Risperidone Schizophrenia Extrapyramidal Prolactin |
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