| 糖尿病合并肺部感染外周血调节性T细胞的检测分析 |
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| 引用本文： | 张志哲,李洪,李家萱,黄天霞.糖尿病合并肺部感染外周血调节性T细胞的检测分析[J].检验医学与临床,2011,8(6):647-648,651. |
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| 作者姓名： | 张志哲 李洪 李家萱 黄天霞 |
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| 作者单位： | 广西医科大学附属南宁市第一人民医院,530022 |
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| 摘 要： | 目的 探讨糖尿病合并肺部感染与CD4+CD25+调节性T细胞的关系.方法 用流式细胞仪分别检测健康对照组32例,单纯糖尿病组20例,糖尿病合并肺部感染组23例的CD4+、CD8+、CD4+CD25+T细胞,计算出CD4+/CD8+、CD4+CD25+/CD4+的比值;用统计学方法比较各组T细胞亚群,用因子分析法分析糖尿病合并肺部感染者T细胞亚群等常见因素的内在联系.结果 糖尿病、糖尿病合并肺部感染组CD8+、CD4+CD25+、CD4+CD25+/CD4+比健康对照组高,CD4+、CD4+/CD8+比健康对照组低,且差异有统计学意义;糖尿病合并肺部感染者年龄、病程、CD4+、CD8+、CD4+/CD8+ 、CD4+CD25+ 、CD4+CD25+/CD4+7个指标之间存在中等偏强的内在联系.结论 CD4+ CD25+T细胞升高可能是糖尿病合并肺部感染难治的原因之一,糖尿病合并肺部感染者常见的7项指标之间存在一定的内在联系.
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| 关 键 词： | 糖尿病 肺部感染 CD4+CD25+调节性T细胞 |
Detection analysis of CD4~+ CD25~+ regulatory T cells in peripheral blood of diabetes mellitus complicating pulmonary infection |
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| ZHANG Zi-zhe,LI Hong,LI Jia-xuan,HUANG Tian-xia.Detection analysis of CD4~+ CD25~+ regulatory T cells in peripheral blood of diabetes mellitus complicating pulmonary infection[J].Laboratory Medicine and Clinic,2011,8(6):647-648,651. |
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| Authors: | ZHANG Zi-zhe LI Hong LI Jia-xuan HUANG Tian-xia |
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| Institution: | (Nanning First People′ s Hospital Affiliated to Guangxi Medical University,Nanning,Guangxi 530022,China) |
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| Abstract: | Objective To investigate the relationship between diabetes complicating pulmonary infection and CD4+ CD25+ regulatory T cells.Methods CD4+ CD25+,CD4+ and CD8+ were measured by flow cytometry in 32 subjects of normal control group,20 cases of simple diabetes mellitus group and 23 cases of diabetes mellitus complicating pulmonary infection group.To compare T cell subsets of each group with statistics,to analyze the relationship among common factors of age,disease course,CD4+,CD8+,CD4+/CD8+,CD4+CD25+,CD4+CD25+... |
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| Keywords: | diabetes pulmonary infection CD4 CD25 regulatory T cells |
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