湛江师范学院2010级新生血清AST、ALT及AST/ALT的检测结果分析

目的 通过对湛江师范学院2010级新生血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)及AST/ALT进行检测,在健康新生中筛查肝功能异常及无症状慢性乙型肝炎.方法 采用日立7020全自动生化仪测定2010级新生血清中AST、ALT及AST/ALT的变化,并对AST、ALT异常的新生进行乙型肝炎两对半的检测.结果 检测出血清ALT和AST异常者42例,占0.80%.无症状慢性乙型肝炎56例,占1.06%.血清ALT和AST升高者,男生高于女生,差异有统计学意义(χ2=9.50,P＜0.01);AST/ALT升高者,男生高于女生,差异也有统计学意义(χ2=6.63,P＜0.01);慢性乙型肝炎男生高于女生,差异有统计学意义(χ2=10.67,P＜0.01),3项结果差异均有统计学意义.结论 在新生体检中进行血清AST、ALT及AST/ALT检测,并对肝功能异常者进行乙型肝炎两对半检测,有利于肝功能异常及无症状慢性乙型肝炎的早期发现和诊治.男生血清AST和ALT、AST/ALT、慢性乙型肝炎异常者高于女生,应引起足够重视.

Analysis on the test results of serum AST,ALT and AST/ALT ratio in the freshmen of grade 2010 of Zhanjiang Normal University

Objective To figure out the proportion of the students with hepatic dysfunction and hepatitis B vi rus among the healthy students of grade 2010 in Zhanjiang normal university through the test of the aspartate aminotransferase（AST） ,Alanine aminotransferase（ALT） and AST/ALT ratio. Methods Firstly,we tested the changes of AST,ALT and the AST/ALT ratio in students＇ serum by Hitachi 7020 automatic biochemical analyzer. Secondly, we tested two pairs of semi-hepatitis B on those students with abnormal AST and ALT. Results There were 42 students with abnormal AST and ALT,56 students with hepatitis B virus,which accounted for 0.80%and 1.06% respectively of the total number. In respect of the increased concentration of AST and ALT, the number of boys was larger than that of girls（X^2 = 9.50, P〈0.01） ;Likewise,in respect of the increased AST/ALT ratio, there were more boys than girls（x^2=6.63,P〈0.01）, and more boys with chronic hepatitis B than that of girls（X^2=10. 67, P% 0.01）. We could see that all of the above three results showed significant difference between boys and girls. Conclu- sion With the test of the AST,ALT and the AST/ALT ratio of freshmen during their physical examinations,and the test of two pairs of semi-hepatitis B on those students with abnormal AST and ALT,students with hepatic dys- function and chronic hepatitis B could be treated in their early time. So we should pay great attention to the fact that the number of boys is larger than that of girls in terms of higher concentration of AST and ALT, higher rates of AST/ALT and chronic hepatitis B.