Comparative analysis between dextran sulfate adsorption and direct adsorption of lipoproteins in their capability to reduce erythrocyte adhesiveness/aggregation in the peripheral blood |
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Authors: | Schechner V Berliner S Shapira I Justo D Hershcovici T Zeltser D Beigel Y |
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Institution: | Department of Internal Medicine A and the Lipid Unit, Rabin Medical Center Campus Beilinson, all affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. |
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Abstract: | The purpose of this study was to compare the degree of erythrocyte adhesiveness/aggregation (EAA) reduction of two low-density lipoprotein (LDL) apheretic procedures, namely direct adsorption of lipoproteins (DALI) and dextran sulfate adsorption (DSA). A significant (P < 0.001) reduction of EAA was noted in six hypercholesterolemic patients who underwent a total of 40 apheretic sessions and no difference was noted in the degree of EAA reduction by the two techniques. Thus. being a real-time and point-of-care test, the erythrocyte adhesiveness/aggregation test can be applied in relevant situations of acute ischemia, where therapeutic LDL apheresis could improve the hemorheology of individuals with increased concentrations of cholesterol and inflammatory sensitive proteins. |
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Keywords: | Erythrocyte adhesiveness aggregation test Low‐density lipoprotein apheresis |
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