Development and characterization of monoclonal antibodies to bovine brain calcineurin |
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| Authors: | H Y Lam |
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| Affiliation: | Department of Medicine, University of Manitoba. |
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| Abstract: | Three monoclonal antibodies (MAb's) against bovine brain calcineurin, a Ca++-calmodulin dependent phosphatase, have been developed and characterized. Among these antibodies, two are alpha-subunit (60,000 Mr) specific and one is beta-subunit (19,000 Mr) specific. These antibodies also cross-react with similar proteins obtained from brains of human, rat and mouse. The methodology for raising these antibodies and their properties are described. |
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