便秘宁对便秘小鼠排便作用的影响

目的 探讨便秘宁对便秘小鼠排便作用的影响。方法 观察不同剂量的便秘宁对正常小鼠、燥结失水便秘模型小鼠肠运动的影响。结果 与对照组相比，不同剂量便秘宁颗粒使燥结失水便秘模型小鼠碳末推进率明显提高（P〈0．01），首次捧便时间明显缩短（P〈0．01），8小时内排便粒数增多（P〈0．05），并能使DC便秘模型小鼠12小时内干、稀粪点数明显增多（P〈0．05）。而大剂量便秘宁颗粒对燥结失水模型及DC模型上述指标与聚乙二醇4000（PEG4000）组相比差异有显著性（P〈0．05）。论讨 便秘宁颗粒能增强便秘小鼠肠运动，大剂量便秘宁对便秘模型小鼠排便作用优于聚乙二醇4000。

The influence of Bianmining on the bowel movement of mice with constipation

Objective To study the influence of Bianmining on bowel movement of mice with constipation.Methods The influences of Bianmining on normal mice with constipation induced by water-free diet and mice with diphenoxylati compositae-indused constipation were observed.Results Bianmining shortened the time of bowel movement in the first time (P<0.01),increased the number of stool granules(P<0.01) and the weight of stool(P<0.01).Biangmining also increased the number of hard stool granule (P<0.01) and wet stool granule(P<0.05). In the trials the effect of Bianmining in large dose was better than PEG4000 group.Conclusion Bianmining can obviously enhance the movement of small intestines.