The time course of protection from delayed neurotoxicity induced by tri-o-cresyl phosphate and O,O-diisopropyl phosphorofluoridate by phenyl methyl sulfonyl fluoride in chickens |
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Authors: | C D Carrington M B Abou-Donia |
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Institution: | Department of Pharmacology, Duke University Medical Center, Durham, NC 27710 U.S.A. |
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Abstract: | The time dependence of the ability of phenyl methyl sulfonyl fluoride (PMSF) to protect adult hens from developing signs of paralysis following the administration of 750 mg/kg tri-ortho-cresyl phosphate (TOCP), p.o., of 1.7 mg/kg O,O-diisopropyl phosphorofluoridate (DFP), s.c., was investigated. PMSF was able to protect the hens from organophosphorus-induced delayed neurotoxicity (OPIDN) when given between 1 and 24 h before the administration of TOCP, or when given 4 h before DFP. However, PMSF was ineffective at preventing paralysis when given 24 h following dosing with TOCP or when given later than 4 h before DFP administration. These results support the notion that PMSF acts at the same site as the organophosphorus esters. |
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Keywords: | Key words not submitted DFP DMSO dimethylsulfoxide NTE neurotoxic esterase OP organophosphorus compound OPIDN organophosphorus-induced delayed neurotoxicity PMSF phenyl methyl sulfonyl fluoride TOCP |
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