| 维生素D受体基因与骨量的关系 |
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| 引用本文： | 仝志琴,马冠生.维生素D受体基因与骨量的关系[J].卫生研究,2006,35(3):370-373. |
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| 作者姓名： | 仝志琴 马冠生 |
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| 作者单位： | 中国疾病预防控制中心营养与食品安全所,北京,100050 |
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| 摘 要： | 近年来对维生素D受体(VDR)基因和骨量关系的研究颇有争议。有许多研究认为维生素D受体基因多态性与骨量有关联。但还有一部分研究未能证实VDR基因多态性与骨量的关联。本文就VDR基因与钙吸收、骨量、药物治疗的关系和VDR基因的协同作用以及与其它基因、环境因素的交互作用对骨量影响的研究进展进行了综述。
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| 关 键 词： | 维生素D受体基因 骨量 维生素D |
| 文章编号： | 1000-8020（2006）03-0370-04 |
| 收稿时间： | 2005-06-27 |
| 修稿时间： | 2005年6月27日 |
Relationships among vitamin D receptor gene and calcium absorption, bone mass |
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| Tong Zhi-qin,Ma Guan-sheng.Relationships among vitamin D receptor gene and calcium absorption, bone mass[J].Journal of Hygiene Research,2006,35(3):370-373. |
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| Authors: | Tong Zhi-qin Ma Guan-sheng |
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| Institution: | Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050,China |
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| Abstract: | The association between vitamin D receptor gene polypmorphisms and bone mass is controversial. Many studies have found polymorphism of vitamin D receptor (VDR) gene be associated with bone mass. But some studies show no association between vitamin D receptor gene polymorphism and bone mass. The relationships among vitamin D receptor gene and calcium absorption,bone mass, drug treatment are reviewed in this article. The interaction between genetic, environmental factors to bone mass is also reviewed. |
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| Keywords: | vitamin D receptor gene bone mass vitamin D |
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