卡马西平过量致偏瘫和偏身感觉障碍

1例51岁女性三叉神经痛患者I：3服卡马西平（0．2g，3次／d）治疗约1年，因疼痛加重1d内累积服用卡马西平2g，第2天在口服卡马西平0．4g之后出现头晕、视物模糊和右侧肢体麻木、无力，遂入院。人院后体格检查：右侧中枢性面舌瘫，咽反射消失，右侧肢体肌力为Ⅳ级，右侧面部及肢体痛觉减退。头部磁共振成像和弥散加权磁共振成像检查未见异常。停用卡马西平，同时给予改善循环药物治疗。4d后患者完全恢复正常。

Hemiplegia and hemidysesthesia induced by excessive dosage of carbamazepine

A 51-year-old female patient with trigeminal neuralgia received carbamazepine 0.2 g thrice daily by mouth for about one year. She took carbamazepine at a cumulative dose of 2 g within one day for aggravated pain. On the second day, the patient developed dizziness, blurred vision, numbness and weakness in her right extremities after taking carbamazepine 0.4 g, and then she was admitted into hospital. Physical examination showed the following results： right central facial and tongue nerve paralysis, absence of pharyngeal reflex, muscle strength of grade 4 in her right limb, hypalgesia in her right side of face and limbs. Examination of cranial magnetic resonance imaging and diffusion-weighted magnetic resonance imaging showed no abnormal changes. Carbamazepine was stopped and drug for improving circulation was given. Four days later, the patient recovered completely.