|
|||||
|
|
Dopamine receptor plasticity following MPTP-induced nigrostriatal lesions in the mouse |
|
| Authors: | Frederic B. Weihmuller John P. Bruno Norton H. Neff Maria Hadjiconstantinou |
| Affiliation: | a Department of Psychology, College of Social and Behavioral Studies, College of Medicine, The Ohio State University, Columbus, OH 43210, U.S.A. b Department of Psychiatry, College of Medicine, The Ohio State University, Columbus, OH 43210, U.S.A. c Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, U.S.A. |
| Abstract: | MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) destroys dopamine-containing nigrostriatal neurons and increases the apparent Bmax of both D1 and D2 binding sites in the striatum. However, the changes of Bmax occur at different intervals after the lesion. Up-regulation of D2 sites becomes evident about 3 weeks after the lesion and lasts for about 3 months. In contrast, about 3 months are required for the up-regulation of D1 sites and increased binding is still evident after 5 months. |
| Keywords: | Dopamine D1 receptors Dopamine D2 receptors Striatum MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Receptor up-regulation |
| 本文献已被 ScienceDirect 等数据库收录！ | |