The use of the antifungal agent miconazole as an inhibitor of Blastocystis hominis growth in Entamoeba histolytica/E. dispar cultures |
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Authors: | Gonçalves Alessandra Queiroga Viana João da Costa Pires Edna Maria Bóia Márcio Neves Coura José Rodrigues Silva Edward Félix |
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Affiliation: | Laboratório de Doen?as Parasitárias, Departamento de Medicina Tropical, Funda??o Oswaldo Cruz, Rio de Janeiro, RJ, Brasil. queiroga@ioc.fiocruz.br |
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Abstract: | In regions with high prevalence, Blastocystis hominis is frequently found in association with Entamoeba histolytica/E. dispar in xenic cultures. Its exacerbated growth is often superimposed on the growth of amebas, thus impeding the continuation of the amebas in the culture, within a few generations. The present study reports on the excellent efficacy (100%) of the antifungal agent miconazole in eliminating B. hominis from cultures of E. histolytica/E. dispar, thereby maintaining the integrity of the trophozoites of the amebas. Nystatin presented low efficacy (33.3%). |
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