| 家蝇抗药性的分子遗传机制 |
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| 引用本文： | 李梅,何凤琴,邱星辉. 家蝇抗药性的分子遗传机制[J]. 寄生虫与医学昆虫学报, 2005, 12(4): 238-244 |
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| 作者姓名： | 李梅 何凤琴 邱星辉 |
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| 作者单位： | 中国科学院动物研究所,农业虫害鼠害综合治理研究国家重点实验室,北京,100080;中国科学院动物研究所,农业虫害鼠害综合治理研究国家重点实验室,北京,100080;中国科学院动物研究所,农业虫害鼠害综合治理研究国家重点实验室,北京,100080 |
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| 基金项目： | 国家自然科学基金资助项目(No.30370946) |
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| 摘 要： | 综述了近年来家蝇抗药性分子机制的研究进展。脂族酯酶基因(MdaE7)在位置137(Gly)和251(Trp)的氨基酸突变可能与家蝇对有机磷抗性有关;谷胱苷肽S转移酶(GSTs)超量表达在家蝇对有机磷农药的抗性中起重要作用;有机磷抗性家蝇的AChE基因普遍存在Gly262Ala和Phe327Tyr突变。击倒抗性(kdr)和P450介导的代谢抗性是家蝇对DDT和拟除虫菊酯类杀虫剂抗性的重要机制,电压门控钠离子通道的L1041F突变产生Kdr,而M918T和L1041F双突变导致超击倒抗性(superkdr);P450介导的代谢抗性表现出进化可塑性的特点。有关家蝇抗性机制的阐明,可为抗性的检测和监测提供准确和方便的手段。
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| 关 键 词： | 家蝇 抗性分子机制 基因突变 |
| 修稿时间： | 2005-04-22 |
THE MOLECULAR BASIS OF INSECTICIDE RESISTANCE OF HOUSEFLY, MUSCA DOMESTICA : A REVIEW |
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| LI Mei,HE Feng-Qin,QIU Xing-Hui. THE MOLECULAR BASIS OF INSECTICIDE RESISTANCE OF HOUSEFLY, MUSCA DOMESTICA : A REVIEW[J]. Acta Parasitologica et Medica Entomologica Sinica, 2005, 12(4): 238-244 |
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| Authors: | LI Mei HE Feng-Qin QIU Xing-Hui |
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| Abstract: | The current progress in the study on molecular basis of insecticide resistance of housefly was reviewed.The mutations in amino acid residues of MdaE7 are associated with the resistance of housefly to organophosphorus compounds(OPS).The over-expression of glutathione S-transferases(GSTs)plays an important role in OP-resistant housefly strains.Kdr and P450-mediated detoxification were found to be the main mechanism of resistance to DDT and pyrethroid pesticides.There are two alleles associated with insensitivity of the voltage sensitive sodium channel:kdr and super-kdr,which result from M918T and M918T/L1014F amino acid substitutions.P450 monooxygenases have some degree of [plasticity in response to pesticide selection.The elucidation of the molecular basis of insecticide resistance will help to develop accurate and rapid tools for detecting and monitoring resistance of pests. |
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| Keywords: | Musca domestica Resistance mechnism Gene mutation |
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