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Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11 |
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| Authors: | Judith S. Nijmeijer Alejandro Arias-Vásquez Nanda N. J. Rommelse Marieke E. Altink Cathelijne J. M. Buschgens Ellen A. Fliers Barbara Franke Ruud B. Minderaa Joseph A. Sergeant Jan K. Buitelaar Pieter J. Hoekstra Catharina A. Hartman |
| Affiliation: | 1. Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands 8. Department of Child and Adolescent Psychiatry, University of Groningen, Hanzeplein 1, PO Box 660, 9700 AR, Groningen, The Netherlands 2. Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands 3. Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands 4. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands 5. Karakter, Child and Adolescent Psychiatry University Medical Center Nijmegen, Nijmegen, The Netherlands 9. Department of Psychiatry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands 6. Youth Department, Lucertis, Parnassia-BAVO-Group, Rotterdam, The Netherlands 7. Department of Clinical Neuropsychology, Vrije Universiteit University Amsterdam, Amsterdam, The Netherlands |
| Abstract: | We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children’s Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing. |
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