肿瘤衍生因子在肿瘤恶病质中的作用及其机制

恶病质是以脂肪组织和骨骼肌消耗为特征的综合征,是许多肿瘤的共同特征,它不仅导致病人生活质量和化疗疗效降低,而且致使生存期缩短.多数病人伴随厌食症及静息能量消耗增加,即使加大营养支持力度也不能逆转恶病质,因此营养不足不是恶病质的根本原因.脂质动员因子(LMF)和蛋白水解诱导因子(PIF)是两种肿瘤衍生因子,分别作用于脂肪组织和骨骼肌,直接动员脂肪酸和氨基酸释放.对LMF与PIF在肿瘤恶病质中的作用及其机制的研究,必然引发恶病质治疗的根本变革.

The roles and mechanism of tumor-derived factors in the development of cancer cachexia

Syndrome of cachexia, which is a common feature of many types of cancer, characterized by loss of adipose tissue and skeletal muscle, is responsib sponse to chemotherapy, but also a decreased survival le not only for a poor quality of life and poor retime. It can not be fully explained by the accompanying anorexia, because increasing nutrient support is unable to reverse the wasting syndrome. Although patients with cachexia frequently show an elevated resting energy expenditure, cachexia can occur with a normal energy expenditure. Lipid mobilizing factor and proteolysis inducing factor, two tumor-de- rived factors, can directly mobilize fatty acids and amino acids from adipose tissue and skeletal muscle respectively. It is important of the knowledge about the roles and mechanism of LMF and PIF in the development of cancer cachexia, which should lead to the development of new therapeutic methods.