首页 | 本学科首页   官方微博 | 高级检索  
检索        


Calcitonin gene-related peptide-like immunoreactivity, in botulinum toxin-paralysed rat muscles
Authors:Sherif M Hassan  Frans GI Jennekens  George Wieneke  Henk Veldman
Institution:

a Laboratory of Neuromuscular Diseases, Department of Neurology, University Hospital Utrecht, Utrecht, The Netherlands

b Division of Clinical Neurophysiology, Department of Neurology, University Hospital Utrecht, Utrecht, The Netherlands

Abstract:Changes in calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) at the motor endplates of botulinum toxin-paralysed rat muscles were investigated using immunohistochemistry. One day following toxin injection, a dramatic increase in CGRP-LI was detected at the motor endplates and within preterminal axons of the soleus and gastrocnemius muscles. The upregulation of CGRP-LI persisted throughout the period during which muscle fibres were paralysed and new neuromuscular junctions were being formed by the growing sprouts. Decline of CGRP-LI at the motor endplates coincided with clinical recovery. Both up- and down-regulation of CGRP-LI took place earlier in the soleus than in the gastrocnemius muscle. Up-regulation of CGRP-LI was also detected in a subpopulation of motor axons in the sciatic nerves and in the spinal motor neurons innervating the paralysed muscles. These results indicate that levels of CGRP are regulated, at least partly, by changes in the target innervation. They also suggest an important role for CGRP in the regenerative processes following muscle paralysis.
Keywords:CGRP  botulinum toxin  motor endplates  motor neurons  sciatic nerve
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号