| 大鼠口服松果菊苷粪便中代谢物的HPLC-MS^n分析 |
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| 引用本文： | 马志国,杨中林,冯云鹏. 大鼠口服松果菊苷粪便中代谢物的HPLC-MS^n分析[J]. 中国天然药物, 2008, 6(5): 387-390 |
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| 作者姓名： | 马志国 杨中林 冯云鹏 |
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| 作者单位： | 中国药科大学现代中药教育部重点实验室,南京210038 |
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| 摘 要： | 目的：研究松果菊苷在大鼠粪便中的代谢物。方法：大鼠灌胃松果菊苷（100mg·kg^-1）后收集粪样，运用高效液相色谱和质谱联用技术检测松果菊苷的代谢产物。结果：在给药后大鼠的粪便中，发现并初步鉴定了4个主要代谢产物。结论：大鼠灌胃给予松果菊苷后，其粪便中的主要代谢产物为毛蕊花糖苷、去咖啡酰基毛蕊花糖苷、黄大花洋地黄苷及3,4-二羟基苯乙醇。
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| 关 键 词： | 松果菊苷 粪便 代谢物 HPLC-MS^n |
Metabolites of Echinacoside in Rats Feces by HPLC-MSn |
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| MA Zhi-Guo,YANG Zhong-Lin,FENG Yun-Peng. Metabolites of Echinacoside in Rats Feces by HPLC-MSn[J]. Chinese JOurnal of Natural Medicines, 2008, 6(5): 387-390 |
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| Authors: | MA Zhi-Guo YANG Zhong-Lin FENG Yun-Peng |
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| Affiliation: | (Key Laboratory of Modern Chinese Medicines, Department of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210038, China) |
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| Abstract: | AIM：To investigate the metabolites of echinacoside in rat feces. METHODS： The feces were collected after oral administration of 100 mg·kg^-1 echinacoside to rats. The samples were detected by LC-MS^n. RESULT： The major metabolites were found in rat feces and their chemical structures were identified primarily. CONCLUSION： The metabolites found in feces are acteoside, decaffeoylacteoside, lugrandoside, 3, 4-dihydroxyphenylethanol. |
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| Keywords: | HPLC-MSn |
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