Composite porosity of expanded polytetrafluoroethylene vascular prosthesis |
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| Affiliation: | 1. Department of Surgery, University of California, Irvine Medical Center, Orange, California, USA;2. Department of Pathology, Harbor-UCLA Medical Center, Los Angeles, California, USA;3. Department of Surgery, Tokyo Medical College, Tokyo, Japan;1. Computer Science Department, Universidad Autónoma de Madrid, Spain;2. Instituto de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València, Spain;1. School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, PR China;2. National Center for International Research of Micro-Nano Molding Technology Zhengzhou University, Zhengzhou 450001, PR China;3. Department of Mechanical Engineering University of Wisconsin–Madison, WI 53706, USA;4. Wisconsin Institute for Discovery University of Wisconsin–Madison, WI 53715, USA;1. Materials Research Laboratory, Wuxi Shunye Technology Co., Ltd., 29 Lianze Road, Shanshui Cheng Technical Park, Suite 15, Binhu District, Wuxi, Jiangsu 214125, China;2. Laboratory for the Analysis of the Surfaces of Materials, Department of Engineering Physics, École Polytechnique de Montréal, Case Postale 6079, succursale Centre-Ville, Montréal, Québec H3C 3A7, Canada;1. State Key Laboratory of Separation Membranes and Membrane Processes, National Center for International Joint Research on Separation Membranes, School of Material Science and Engineering, Tiangong University, 399 Binshui West Road, Tianjin, 300387, PR China;2. College of Chemistry and Chemical Engineering, Yantai University, Yantai, 264005, PR China;3. Fiber Materials Research Center, Shanghai University of Engineering Science, Shanghai, 201620, PR China |
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| Abstract: | Polytetrafluoroethylene (PTFE) prostheses were modified to produce two types of composite porosity PTFE grafts: type I — inner 60 μm/outer 20 μm and type II — inner 20 μm/outer 60 μm. These composite porosity PTFE designs were investigated for bleed through, graft healing and patency and compared with high porosity PTFE (60 μm) and standard PTFE (20 μm) grafts. The grafts were implanted into the carotid and femoral arteries of dogs and retrieved after 4, 12 and 18 weeks. Both composite porosity grafts showed significantly less bleed through than standard and high porosity grafts after reperfusion. In composite grafts, the 60-μm layer allowed fibrovascular tissue and histiocyte ingrowth from perigraft tissue, but the 20-μm layer did not. Neointima formation occurred earlier and endothelialization was more extensive in high porosity grafts, but seroma formation occurred in 25% of cases. In type I composite porosity grafts, smooth muscle cells of neointima migrated into the pores of the graft, providing a firmly anchored intima. Type II composite porosity grafts allowed better ingrowth of fibrovascular tissue at the outer layer from the perigraft tissue; however, endothelialization was not completed. Composite porosity grafts should be considered for evaluation in specific clinical situations. |
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