Increases in src-related protein tyrosine kinases in human liver cirrhosis and hepatocellular carcinoma |
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| Affiliation: | 1. The Third Department of Internal Medicine, Kagawa Medical School, 1750-1 Ikenobe Miki-cho, Kagawa, 761-07, Japan;2. Departments of Physiology, Kagawa Medical School, 1750-1 Ikenobe Miki-cho, Kagawa, 761-07, Japan;3. The First Department of Surgery, Kagawa Medical School, 1750-1 Ikenobe Miki-cho, Kagawa, 761-07, Japan;4. The Second Department of Surgery, Kagawa Medical School, 1750-1 Ikenobe Miki-cho, Kagawa, 761-07, Japan;5. Takamatsu National Hospital, Otsu Shindeu-cho, Kagawa 761-01, Japan |
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| Abstract: | We examined the involvement of src-related tyrosine kinases (RTK) in various human liver diseases, such as chronic hepatitis (CH), liver cirrhosis (LC) and hepatocellular careinoma (HCC), by Western blot and immunohistochemical analysis using an anti-src-RTK polyclonal antibody (α-416). Our results showed that src-RTK were rarely found in the liver tissues from CH patients, while they were found at high amounts in those from LC and HCC patients. In addition, src-RTK were expressed more strongly in HCC than in LC. These results indicate that src-RTK may play important roles in the occurrence and development of LC and HCC. |
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