Effects of chronic use of carbamazepine and valproate on cognitive processes |
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| Institution: | 1. Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan;2. Department of NCNP Brain Physiology and Pathology, Division of Cognitive and Behavioral Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan;1. Behavioral Sleep Medicine Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA;2. Center for Sleep and Circadian Neurobiology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA;3. School or Nursing, University of Pennsylvania, Philadelphia, PA, USA;4. Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA;5. Mood and Anxiety Disorders Treatment and Research Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA;6. Department of Psychology, University of Arizona, Tucson, AZ, USA;7. Department of Psychiatry, University of Rochester, Rochester, NY, USA |
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| Abstract: | We investigated effects on cognitive processes of chronic use of carbamazepine (CBZ) and valproate (VPA) in a group of young patients with epilepsy. Scores on various neuropsychological tests were obtained from patients treated with two monotherapy regimens, one involving CBZ and one involving VPA. In general, the cognitive profile of the two antiepileptic drugs (AEDs) was the same, except for some attention and memory aspects on which the VPA subjects scored better and for some motor tests which the CBZ group performed faster. The latter finding is in accord with results of studies reporting an increase in motor speed induced by CBZ. Furthermore, the observed impairments caused by both CBZ and VPA were relatively mild as compared with those caused by traditional AEDs such as phenytoin (PHT) and phenobarbital (PB). |
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