Bacteremia is required for invasion of the murine central nervous system by Listeria monocytogenes |
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| Affiliation: | 1. Clinic of Swine and Small Ruminants, Forensic Medicine and Ambulatory Service, University of Veterinary Medicine Hannover, Germany;2. Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany;3. Department of Pediatric Pulmonology and Neonatology, Hannover Medical School, Hannover, Germany;4. Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany;1. Department of Microbiology, Immunology, Parasitology and Pathology, Tropical Pathology and Public Health Institute, Federal University of Goias, Rua 235 S/N, Setor Universitário, 74605-050 Goiânia, Goiás, Brazil;2. Medicine Faculty, UNIRG – Univeristy Center, Avenida Antônio Nunes da Silva n° 2195, Pq. das Acácias, 77425-500 Gurupi, Tocantins, Brazil |
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| Abstract: | The ability of the facultative intracellular pathogenListeria monocytogenesto penetrate the central nervous system (CNS) was studied by following the kinetics of brain invasion and histological lesions during an acute intravenous (i.v.) infection in the mouse. CNS invasion occurred during the early phase of infection and produced severe meningoencephalitis characterized by multiple granulomatous foci predominantly located in the brainstem and associated with diffuse meningitis and an intense inflammatory reaction involving the choroid plexuses. Bacterial counts in the brain could reach 104.5–105.8by day 5 of infection with 1–2×106bacteria i.v., depending upon the bacterial strain used. It was found that CNS invasion was highly dependent upon the level and the duration of bacteremia, thus indicating that persistent bacteremia is essential to induce meningoencephalitis toL. monocytogenes. |
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