Cocaethylene-induced lethality in mice is potentiated by alcohol |
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| Affiliation: | 1. Department of Legal Medicine, University of Sao Paulo Medical School, Av. Dr. Arnaldo, 455 - Cerqueira César, São Paulo SP 01246-903, Brazil;2. Department of Forensic Sciences, Oslo University Hospital, Oslo, P.O. Box 4950 Nydalen, NO-0424, Norway;3. Department of Preventive Medicine, University of Sao Paulo Medical School, Av. Dr. Arnaldo, 455 - Cerqueira César, São Paulo SP 01246-903, Brazil;4. Department of Surgery, Clinical Hospital of the University of Sao Paulo Medical School, Av. Dr. Enéas Carvalho de Aguiar, 255 - Cerqueira César, São Paulo SP 05403-000, Brazil;5. Department of Traumatology and Orthopedics, Clinical Hospital of the University of Sao Paulo Medical School, R. Dr. Ovídio Pires de Campos, 333 - Cerqueira César, São Paulo SP 05403-010, Brazil;1. Poison Control Center of São Paulo, São Paulo, SP 04330-020, Brazil;2. Pharmacosciences Department, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS 90050-170, Brazil;3. Department of Preventive Medicine, Federal University of São Paulo, São Paulo, SP 04023-062, Brazil;4. School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil |
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| Abstract: | Mice of the heterogeneously bred HS line were concurrently administered intraperitoneal injections of either 95, 75, 60, or 48 mg/kg Ccaehylene or 48, 38, or 30 mg/kg cocaethylene in conjunction with the non-lethal dose of 6.0 g/kg (20% w/v) alcohol. Results indicate that alcohol administration significantly potentiated cocaethylene-induced lethality. This observation suggests that alcohol is capable of enhancing the lethal effects of Ccaehylene. Results are discussed in terms of observations of sudden death in humans who abuse cocaine and alcohol. |
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