Characterization of hepatitis C virus antibody positive blood donors in Japan and Thailand: a comparative study |
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| Affiliation: | 1. Japanese Red Cross Tokyo Metropolitan Blood Centre, 1-26-1 Kyonan-cho, Musashino, Tokyo 180, Japan;2. National Blood Centre, Thai Red Cross Society, Henri Dunant Road, Bangkok 10330, Thailand;1. School of Environment, Tsinghua University, Beijing 100084, China;2. Key Laboratory for Solid Waste Management and Environment Safety (Tsinghua University), Ministry of Education of China, Tsinghua University, Beijing 100084, China;3. Dept of Civil, Environ & Geomatic Eng, University College London, London WC1E 6BT, UK;1. College of Economics and Management, China Three Gorges University, Yichang 443002, China;2. Business School, Hohai University, Nanjing 211100, China;3. Department of Architecture Science, Toronto Metropolitan University (Formerly Ryerson University), Toronto, ON M5B 2K3, Canada;1. Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan;2. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan;3. Center for Information and Neural Networks, 1-4 Yamadaoka, Suita City, Osaka, 565-0871, Japan;4. Institute for AI and Beyond, The University of Tokyo, Tokyo 113-0033, Japan;1. Institute for Energy Research, School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, PR China;2. School of Chemistry and Chemical Engineering, National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology, Nanjing, 210094, PR China |
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| Abstract: | The assay of specific antibodies to hepatitis C virus (anti-HCV) was introduced in the screening of donated blood in November 1989 in Japan and in January 1991 in Thailand. Anti-HCV-positive rates obtained using commercial second-generation kits on donated blood in both countries are similar. However we found differences in the serum alanine aminotransferase (ALT) values of anti-HCV-positive donors between the two countries: 57.0% of anti-HCV-positive Thai donors showed elevated ALT values, whereas only 23.7% of anti-HCV-positive Japanese donors did. Furthermore, different distributions of HCV genotypes were observed among anti-HCV-positive donors of the two countries. Although type 1b showed the highest prevalence among donors in both countries, type 1a showed the lowest prevalence in Japanese donors and the second-highest prevalence in Thai donors. We also examined the HCV RNA levels using a branched DNA probe assay in serum samples of Thai donors and observed no significant relationships between ALT value and HCV genotype or HCV RNA level, although HCV RNA levels in genotype 1b Japanese donors were higher than that in genotype 2a Japanese donors. |
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