Impaired antigen presention by splenocytes of ethanol-consuming C57BL/6 mice |
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| Affiliation: | 1. Pancreatic Surgery Unit, Humanitas Clinical and Research Center – IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy;2. Humanitas University Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, Italy;3. Division of Biostatistics, Department of Oncology, Humanitas Clinical and Research Center – IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy;4. Department of Pathology, Humanitas Clinical and Research Center – IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy;5. Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center – IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy;6. Department of Oncology, Humanitas Clinical and Research Center – IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy;1. Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China;2. Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China |
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| Abstract: | Excessive alcohol consumption impairs T-cell-dependent immune function. Whether this impairment results from the direct inhibition of helper T (Th) cells or from inhibition of the cells that process and present antigen to Th cells is unclear. The present study examines the effect of dietary alcohol on the ability of spleen cells from C57BL/6 mice to present antigen to T-cell hybridomas. We find that ethanol consumption impairs the ability of spleen cells to present hen egg lysozyme (HEL) in vitro. This impairment was seen for native HEL protein, a hapten-modified HEL, and a peptide bearing a minimal T-cell epitope (HEL 51–60) that requires no additional enzymatic processing. These results suggest that deficiencies in immune responsiveness in alcohol-consuming individuals may include antigen presentation. |
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