| 精子的表观遗传学与胚胎发育关系的研究进展 |
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| 引用本文： | 何燕芳,;马洁桦,;潘连军,;黄宇烽.精子的表观遗传学与胚胎发育关系的研究进展[J].中华男科学杂志,2014(8):734-737. |
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| 作者姓名： | 何燕芳 ;马洁桦 ;潘连军 ;黄宇烽 |
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| 作者单位： | [1]南京医科大学第二附属医院儿童医学中心,江苏南京210003; [2]南京医科大学附属南京妇幼保健院泌尿男科,江苏南京210004; [3]南京军区南京总医院解放军临床检验医学研究所,江苏南京210002 |
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| 基金项目： | 国家自然科学基金（30972995）;南京医科大学科技发展基金（2013NJMU127） |
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| 摘 要： | 表观遗传学是研究DNA序列未发生变化但表型发生可遗传改变的一门学科。精子在其发生和受精过程中表观遗传信息都发生了较大变化,而这些改变将直接影响受精后的胚胎发育,因此研究精子的表观遗传学与胚胎发育有重要的意义。本文从精子的DNA甲基化、组蛋白修饰、非编码RNA调控和基因印记4个方面对精子的表观遗传学改变及其对胚胎发育的影响作简要探讨。
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| 关 键 词： | 精子 表观遗传学 胚胎发育 |
Relationship between epigenetics of sperm and embryogenesis |
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| Institution: | HE Yan-fang, MA Jie-hua, PAN Lian-jun, HUANG Yu-feng( 1. Center of Pediatrics, The Second Affiliated Hospititute of Clinical Laboratory Medicine, Nanfing General Hospital of Nanfing Military Region, Nanjing, Jiangsu 210002, China)tal of Nanfing Medical University, Nanjing, Jiangsu 210003, China; 2. Department of Andrology and Urology, Nanjing Maternity and Child Healthcare Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004, China; 3. PLA Research Ins |
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| Abstract: | Abstract] Epigenetics comprises the modifications made in gene expressions without changing the DNA sequence itself. Signifi- cant epigenetic changes take place during spermatogenesis and fertilization and exert direct influences on embryogenesis. This article provides an overview of the latest researches on epigenetics of male germ cells and a brief discussion on the correlation of sperm with emhryogenesis in four aspects： DNA methylation, histone modification, regulation of non-coding RNAs, and genomic imprinting. |
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| Keywords: | sperm epigenetics embryogenesis |
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