| 精子发生过程中的表观遗传学调控 |
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| 引用本文： | 徐晨,宋宁.精子发生过程中的表观遗传学调控[J].中华男科学杂志,2014(5):387-391. |
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| 作者姓名： | 徐晨 宋宁 |
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| 作者单位： | [1]上海交通大学医学院解剖与组织胚胎学系 [2]上海市生殖医学重点实验室,上海200025 |
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| 基金项目： | 国家自然科学基金（30771139） |
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| 摘 要： | 精子发生是由精原细胞增殖、精母细胞减数分裂以及精子形成所组成的连续过程。精子发生也是染色质不断凝集的过程,最终在精子头部达到高度浓缩状态。近年来的研究表明,表观遗传调控在精子发生过程中发挥作用。我们将从三方面简要阐述精子发生过程中的表观遗传学调控机制:DNA甲基化,组蛋白修饰以及非编码RNA。这些表观因素之间也可以互相调控,通过调控基因表达、转座子活化、性染色体失活以及基因印记等,在精子发生,受精以及胚胎发育过程中扮演重要角色。
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| 关 键 词： | 精子发生 表观遗传学 DNA甲基化 组蛋白修饰 非编码RNA |
Epigenetic Regulation in Spermatogenesis |
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| XU Chen,SONG Ning.Epigenetic Regulation in Spermatogenesis[J].National Journal of Andrology,2014(5):387-391. |
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| Authors: | XU Chen SONG Ning |
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| Institution: | ( Department of Anatomy, Histology and Embryology ! Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China) |
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| Abstract: | Spermatogenesis is a process consisting of spermatogonial proliferation, spermatocytic meiosis, and spermiogenesis, and is also considered to be a process in which heterochromatins gradually aggregate and finally reach a highly condensed formation in the sperm head. Recent studies show that epigenetic regulation plays a key role in spermatogenesis. This review discusses the mecha- nisms of epigenetic regulation in spermatogenesis in three aspects, DNA methylation, histone modification, and noncoding RNAs. These factors are essential for spermatogenesis, fertilization, and embryogenesis by mutual regulation as well as by gene expression reg- ulation, transposon activation, sex chromosome inactivation, and genome imprinting. Natl J Androl, 2014, 20 （5）： 387-391 |
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| Keywords: | spermatogenesis epigenetics DNA methylation histone modifications noncoding RNA |
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