直肠癌治疗术后勃起功能障碍的发病机制

直肠癌是常见的消化道恶性肿瘤之一,近年来发病率逐年上升。目前治疗方法包括手术治疗、放化疗以及多种方式联合的综合治疗。性功能障碍尤其是勃起功能障碍(ED)是男性直肠癌治疗术后最常见的并发症之一,严重降低了患者术后的生活质量,既往公认其主要原因是损伤了盆腔自主神经。近年的研究发现其发病机制不仅如此,而是一个复杂的病理生理过程,包括神经、血管、心理因素等。现就直肠癌治疗术后ED的发病机制作一综述,为临床上预防和治疗术后ED提供理论依据,从而降低其发生率,提高患者的生活质量。

Pathogeneses of erectile dysfunction after rectal cancer treatment

Rectal cancer is a common malignancy in the alimentary tract with an increasing incidence, the current treatments of which include surgery, radiotherapy, chemotherapy, and integrated comprehensive options. Sexual dysfunction, especially erectile dysfunction （ED）, is one of the commonest complications in men after rectal cancer treatment and is generally attributed to the damage to the pelvic autonomic nerves. However, recent studies show that ED after rectal cancer treatment is a complex pathophysiological process associated with neurogenic, vasculogenie, and psychological factors. This article reviews the pathogeneses of ED after rectal cancer treatment in order to provide some theoretical evidence for its prevention and treatment.