| 自噬与前列腺癌 |
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| 引用本文： | 李卫平,王施广,郭秀全,王养民.自噬与前列腺癌[J].中华男科学杂志,2014(3):277-280. |
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| 作者姓名： | 李卫平 王施广 郭秀全 王养民 |
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| 作者单位： | [1]兰州军区总医院泌尿外科 [2]兰州大学第二临床医学院泌尿外科,甘肃兰州730000 |
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| 摘 要： | 自噬作用被认为具有高度复杂性及环境依赖性,在有些肿瘤中表现为肿瘤抑制和促进相对立两方面影响,比如乳腺癌和前列腺癌。本文综述了自噬对前列腺癌的发生、发展及治疗的最新研究进展。重点突出自噬调节在雄激素剥夺期间的影响,讨论了雄激素对前列腺癌细胞自噬作用所产生的调节效应。通过对一些研究的报道结果进行评价、分析,我们认为:自噬抑制并结合抗雄激素治疗对于前列腺癌是非常有前景的新型治疗方法。
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| 关 键 词： | 自噬 凋亡 前列腺癌 |
Autophagy and prostate cancer |
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| LI Wei-ping,WANG Shi-guang,GUO Xiu-quan,WANG Yang-min.Autophagy and prostate cancer[J].National Journal of Andrology,2014(3):277-280. |
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| Authors: | LI Wei-ping WANG Shi-guang GUO Xiu-quan WANG Yang-min |
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| Institution: | 1. Department of Urology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou, Gansu 730000, China ; 2. Department of Urology, The Second School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu 730000, China) |
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| Abstract: | The role of autophagy is known to be highly complex and context-dependent, and may be characterized as both tumor suppression and tumor promotion in some tumors, such as breast cancer and prostate cancer. This review outlines recent advances in the studies of the involvement of autophagy in the development, progression and treatment of prostate cancer, focusing on autophagy modulation during androgen deprivation, with a special discussion on the regulatory effect of androgens on the autophagy of prostate cancer cells. A critical evaluation and analysis of the studies suggests that autophagy inhibition combined with androgen deprivation therapy is a promising approach to the treatment of prostate cancer. Natl J Atulrol, 2014, 20 （3） ： 277 -280 |
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| Keywords: | autophagy apoptosis prostate cancer |
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