| 单核苷酸多态性与前列腺癌的研究进展 |
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| 引用本文： | 马超,刘春晓,黄鹏. 单核苷酸多态性与前列腺癌的研究进展[J]. 中华男科学杂志, 2014, 0(8): 738-742 |
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| 作者姓名： | 马超 刘春晓 黄鹏 |
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| 作者单位： | 南方医科大学珠江医院泌尿外科,广东广州510280 |
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| 基金项目： | 广州市珠江科技新星基金资助项目（2013J2200044） |
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| 摘 要： | 前列腺癌是影响西方国家男性健康的常见恶性肿瘤,而单核苷酸多态性(SNPs)作为第3代遗传标记可以影响到前列腺癌的发生、发展及预后。相同SNPs在不同种族间和前列腺癌的关系可能存在差异;本文就与前列腺癌相关的基因进行分类,描述不同SNPs与前列腺癌的关系。SNPs可以预测前列腺癌治疗过程中可能的不良反应,同时也可预测前列腺癌的患病风险,但目前仍存在一定的局限。
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| 关 键 词： | 单核苷酸多态性 前列腺癌 |
Single nucleotide polymorphisms and prostate cancer |
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| MA Chao,LIU Chun-xiao,HUANG Peng. Single nucleotide polymorphisms and prostate cancer[J]. National journal of andrology, 2014, 0(8): 738-742 |
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| Authors: | MA Chao LIU Chun-xiao HUANG Peng |
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| Affiliation: | (Department of Urology, Zhufiang Hospital, Southern Medical University, Guangzhou , Guangdong 510282, China) |
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| Abstract: | Prostate cancer is a common malignancy that affects men＇s health in the Western countries. Single nucleotide polymor- phisms （SNPs）, as the third generation of genetic markers, can influence the development, progression, and prognosis of prostate cancer. The same SNP may be related differently with prostate cancer among different races. This paper describes the relationship be- tween SNPs and prostate cancer according to their related genes. SNPs can predict the risk of prostate cancer as well as the possible ad- verse reactions in its treatment, but at present they do have some limitations. |
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| Keywords: | single nucleotide polymorphism prostate cancer |
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