| 3-奎宁环酮的制备 |
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| 引用本文： | 杨志杰,陶开跃,金华龙,金志华.3-奎宁环酮的制备[J].中国医药工业杂志,2007,38(4):260-261. |
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| 作者姓名： | 杨志杰 陶开跃 金华龙 金志华 |
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| 作者单位： | 浙江大学宁波理工学院,浙江,宁波,315100 |
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| 摘 要： | 4-哌啶甲酸在三甲基氯硅烷作用下酯化、与溴乙酸乙酯进行N-烷基化反应制得1-乙氧甲酰基甲基哌啶-4-甲酸乙酯，再经Dieckmann反应制得药物中间体3-奎宁环酮，总收率约70％。
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| 关 键 词： | 3-奎宁环酮 中间体 制备 |
| 文章编号： | 1001-8255（2007）04-0260-02 |
| 修稿时间： | 2006-05-12 |
Preparation of 3-Quinuclidone |
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| Authors: | YANG Zhi-jie TAO Kai-yue JIN Hua-long JIN Zhi-hua |
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| Institution: | Dept. of Biological and Pharmaceutical Engineering, Ningbo Institute of Technology, Zhejiang University, Ningbo 315100 |
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| Abstract: | 3-Quinuclidone, the key intermediate for some drugs, was prepared from piperidine-4-carboxylic acid by esterification with alcohol in the presence of chlorotrimethylsilane, N-alkylation with ethyl bromoacetate in ethanol to give ethyl 1-carbethoxymethylpiperidine-4-carboxylate followed by Dieckmann reaction with an overall yield of about 70 %. |
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| Keywords: | 3-quinuclidone intermediate preparation |
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