A Young Child with Eosinophilia,Rash, and Multisystem Illness: Drug Rash,Eosinophilia, and Systemic Symptoms Syndrome After Receipt of Fluoxetine |
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| Authors: | Pandiarajan Vignesh M.D. Janak Kishore M.D. Ankur Kumar M.D. Keshavamurthy Vinay M.D. Sunil Dogra M.D. Sreejesh Sreedharanunni M.D. Prabhas Prasun Giri M.D. Priyankar Pal M.D. Apurba Ghosh M.D. |
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| Affiliation: | 1. Pediatric Allergy Immunology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India;2. Serology and Molecular Virology, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Education, Lucknow, Uttar Pradesh, India;3. Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;4. Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;5. Department of Pediatric Medicine, Institute of Child Health, Kolkatta, West Bengal, India |
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| Abstract: | Drug rash, eosinophilia, and systemic symptoms (DRESS) syndrome is a severe systemic hypersensitivity reaction that usually occurs within 6 weeks of exposure to the offending drug. Diagnosis is usually straightforward in patients with pyrexia, skin rash, hepatitis, and eosinophilia with a preceding history of exposure to agents often associated with DRESS syndrome, such as aromatic anticonvulsants and sulfa drugs, but diagnosis of DRESS may still be a challenge. We report a 4‐year‐old child with probable DRESS syndrome complicated by multiple hematologic complications that developed 1 month after exposure to fluoxetine, a drug not known to be associated with such severe reactions. |
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