Topical Cidofovir for Recalcitrant Verrucae in Individuals with Severe Combined Immunodeficiency After Hematopoietic Stem Cell Transplantation |
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| Authors: | Sarah E Henrickson MD PhD James R Treat MD |
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| Institution: | 1. Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania;2. Section of Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania |
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| Abstract: | Verrucae vulgaris in patients with severe combined immunodeficiency (SCID) after hematopoietic stem cell transplantation (HCST) can be challenging to manage. We describe two brothers with X‐linked SCID who had severe, persistent verrucae that did not respond to traditional topical therapies, including liquid nitrogen, imiquimod, salicylic acid, sinecatechins, 40% urea, and 5‐fluorourcil. Both brothers had full response to topical 3% cidofovir, which should be considered in recalcitrant warts in individuals with SCID after HSCT. |
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