Proinflammatory and anti-inflammatory cytokines in meningococcal disease |
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| Authors: | FA Riordan O Marzouk AP Thomson JA Sills CA Hart |
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| Affiliation: | Institute of Child Health, University of Liverpool. |
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| Abstract: | Interleukin-10 (IL-10), an anti-inflammatory cytokine, was measured in 131 children with meningococcal disease. IL-10 concentrations were significantly higher in children who died and correlated positively with proinflammatory cytokines. Children who die from meningococcal disease have high IL-10 concentrations, which do not suppress proinflammatory cytokines. |
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