Anti-glomerular basement membrane disease and dual positivity for antineutrophil cytoplasmic antibody in a patient with membranous nephropathy |
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| Authors: | IS Meisels IE Stillman AB Kuhlik |
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| Affiliation: | Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. ism1@prodigy.net |
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| Abstract: | We present the case of a 50-year-old man who underwent kidney biopsy for nephrotic syndrome. In addition to a membranous pattern, anti-glomerular basement membrane (anti-GBM) staining was noted before manifestations of anti-GBM disease. Hematuria and renal failure ensued 2 weeks later. In addition, he had simultaneous circulating levels of anti-GBM antibody and both perinuclear (P-) and cytoplasmic (C-) antineutrophil cytoplasmic antibody (ANCA). |
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