Characterization of endometrial T lymphocyte subpopulations in spontaneous early pregnancy loss |
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Authors: | Vassiliadou N; Bulmer JN |
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Institution: | Department of Pathology, University of Newcastle, Royal Victoria Infirmary, Newcastle upon Tyne, UK. |
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Abstract: | T lymphocyte subpopulations were compared in normal first trimester human
decidua and in decidua associated with spontaneous abortion. Cryostat
sections were labelled using a panel of monoclonal antibodies specific for
CD3, CD8, CD4 and for the alphabeta and gammadelta heterodimers of the T
cell receptor using an avidin-biotin complex peroxidase method. All the
endometrial T cell subsets which have been demonstrated in normal early
pregnancy were detected in similar numbers and proportions in spontaneous
abortion. The findings suggest that adverse pregnancy outcome is not
influenced by altered proportions of T cell subpopulations; nevertheless,
the possibility remains that these cells may have an altered antigenic
phenotype in spontaneous abortion which could contribute to pregnancy
success or failure.
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Keywords: | |
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