| Rho/Rho激酶信号通路与缺血性脑血管病 |
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| 引用本文： | 王志,曹秉振.Rho/Rho激酶信号通路与缺血性脑血管病[J].国际脑血管病杂志,2008,16(5). |
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| 作者姓名： | 王志 曹秉振 |
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| 作者单位： | 济南军区总医院神经内科,250031;济南军区总医院神经内科,250031 |
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| 摘 要： | Rho/Rho激酶信号通路是体内普遍存在的一条信号通路,它通过调节细胞内肌动蛋白骨架的聚合状态而扮演着"分子开关"角色,参与多种细胞功能.Rho/Rho激酶信号通路在缺血性脑血管病的危险因素、发病机制和病理生理学过程中发挥着重要作用,抑制Rho/Rho激酶信号通路能够取得显著的神经保护作用.
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| 关 键 词： | Rho/Rho激酶 缺血性脑血管病 脑损伤 内皮细胞 |
Rho/Rho-Kinase Signaling Pathway and Ischemic Cerebrovascular Disease |
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| Zhi Wang,Bing-Zhen Cao.Rho/Rho-Kinase Signaling Pathway and Ischemic Cerebrovascular Disease[J].International Journal of Cerebrovascular Diseases,2008,16(5). |
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| Authors: | Zhi Wang Bing-Zhen Cao |
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| Abstract: | Rho/Rho-kinase signaling pathway is a ubiquitous one in vivo.It plays a role of "molecular switch"by regulating the polymeric state of intracellular actin cytoskeleton,and participates in the regulation of various cellular functions.Rho/Rho-kinase signaling pathway plays an important role in the risk factors.pathogenesis and pathophysiological processes of ischemic cerebrovascular disease.The inhibition of Rho/Rho-kinase signaling pathway may achieve a significant neuroprotective effect. |
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| Keywords: | Rho/Rho-kimse ischemic cerebrovascular disease brain injury endothelium |
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