Primary combined-modality therapy for esophageal cancer |
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Authors: | Minsky Bruce D |
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Affiliation: | Weill Medical College of Cornell University, Department of Radiation Oncology, Memorial Sloan-Kettering, Cancer Center, New York, New York, 10021, USA. |
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Abstract: | Based on positive results from the Radiation Therapy Oncology Group (RTOG) 85-01 trial, the conventional nonsurgical treatment of esophageal carcinoma is combined-modality therapy. Dose intensification of the RTOG 85-01 regimen, examined in the Intergroup (INT)-0123/RTOG 94-05 trial, did not improve local control or survival. Areas of clinical investigation include the development of combined-modality therapy regimens with newer systemic agents, the use of 18F-fluorodeoxyglucose positron-emission tomography to assist in the development of innovative radiation treatment planning techniques, and the identification of prognostic molecular markers. The addition of surgery following primary combined-modality therapy apparently does not improve survival, but this finding is controversial. |
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