| MOUSE ANTIBODY RESPONSE FOLLOWING REPETITIVE INJECTIONS OF GAMMA－IRRADIATED HUMAN PLACENTA COLLAGEN |
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| 引用本文： | 刘秉慈,许增禄.MOUSE ANTIBODY RESPONSE FOLLOWING REPETITIVE INJECTIONS OF GAMMA－IRRADIATED HUMAN PLACENTA COLLAGEN[J].中国医学科学杂志,1994(2). |
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| 作者姓名： | 刘秉慈 许增禄 |
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| 作者单位： | Chinese Academy of Preventive Medicine，Institute of Occupational Medicine，Beijing 100050 |
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| 摘 要： | ＭＯＵＳＥＡＮＴＩＢＯＤＹＲＥＳＰＯＮＳＥＦＯＬＬＯＷＩＮＧＲＥＰＥＴＩＴＩＶＥＩＮＪＥＣＴＩＯＮＳＯＦＧＡＭＭＡ－ＩＲＲＡＤＩＡＴＥＤＨＵＭＡＮＰＬＡＣＥＮＴＡＣＯＬＬＡＧＥＮ￥ＬｉｕＢｉｎｇｃｉ（刘秉慈）；ＭｅｌｖｉｎＳｐｉｒａａｎｄＸｕＺｅｎｇ...
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MOUSE ANTIBODY RESPONSE FOLLOWING REPETITIVE INJECTIONS OF GAMMA-IRRADIATED HUMAN PLACENTA COLLAGEN |
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| Liu Bingci, Melvin Spira and Xu Zenglu.MOUSE ANTIBODY RESPONSE FOLLOWING REPETITIVE INJECTIONS OF GAMMA-IRRADIATED HUMAN PLACENTA COLLAGEN[J].Chinese Medical Sciences Journal,1994(2). |
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| Authors: | Liu Bingci Melvin Spira and Xu Zenglu |
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| Abstract: | Injectable bovine collagen has been used clinically for years. But both the necessity of repeated injections to maintain corrections and the question of adverse allergic reactions developing from the use of a xenogenic collagen have been an area of serious concern. To overoome these adverse effects, we have developed injectable collagen preparations from human placenta. Gamma irradiation was used for sterilization and crosslinkins of the collagen.We observed the mouse immune respose to gamma-irradiated human placenta soluble and insoluble collagen following multiple injections. After six injections of these materials, no total IgG level increase was found, nor was antibody specifically directed against human collagen found.Mouse antibody levels were also observed following Zyderm II and Zyplast repetitive injections and following repetitive implantations of coated vicryl and chromic gut. No humoral immune response was found in this heterologous type system. |
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| Keywords: | antibody placenta collagen |
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