慢性B淋巴细胞白血病CD4^＋CD25^＋highCD127^Low和CD19^＋-CD23^＋的相关性研究

目的通过研究慢性B淋巴细胞白血病（chronic B cell lymphocytic leukemia，B—CLL）CD4^＋CD25^＋highCDl27^Low和CD19^＋CD23^＋的相关性，探讨CD4^＋CD25^＋highCDl27^Low在B—CLL发生发展过程中的作用。方法将20例初次发病的B—CLL患者按临床分期的不同分为O-II期组、III-IV期组，设立正常对照组，应用流式细胞仪检测各组的研究对象外周血中CD4^＋CD25^＋highCDl27^Low、CD19^＋、CD19^＋CD23^＋的表达量，比较各组间的差异。结果B—CLL O-II期组、III-IV期组患者外周血中CD4^＋CD25^＋highCDl27^Low、CD19^＋、CD19^＋CD23^＋的表达量均明显高于正常对照组；B—CLL患者III-IV期组的CD4^＋CD25^＋highCDl27^Low、CDl9^＋、CDl9^＋CD23^＋表达量明显高于O-II期组；CD4^＋CD25^＋highCDl27^Low、CDl9^＋CD23^＋有明显的正相关性。结论B—CLL患者外周血中CD4^＋CD25^＋highCD127^Low的表达量增高，与CD19^＋、CD19^＋CD23^＋的表达量增高明显相关，可能是B—CLL患者CD19^＋CD23^＋克隆性增生原因之一．

Correlation of CD4+CD25+/highCD127Low with CD19+CD23+ in patients with chronic B cell lymphocytic leukemia

Objective To investigate the correlation of CD4^＋CD25^＋highCDl27^Low with CD19^＋CD23^＋ in patients with chronic B cell lymphocytic leukemia （B-CLL）. Methods Twenty cases of B-CLL were classified as phase O-II group and phase Ill-IV group. CD4^＋CD25^＋highCDl27^Low, CD19^＋, CD19^＋CD23^＋ were analyzed by flow cytometry. Results CD4^＋CD25^＋highCDl27^Low, CD19^＋ and CD19^＋CD23^＋ in B-CLL patients were significantly higher than those of normal controls; and the above markers in phase Ill-IV group were significantly higher than those in phase O-II group. There was a positive correlation of CD4^＋CD25^＋highCDl27^Low with CD19^＋ and CD19^＋CD23^＋. Conclusion CD4^＋CD25^＋highCDl27^Low is highly expressed in B-CLL and is positively correlated with CD19^＋ and CD19^＋/CD23^＋,which may be a main cause of CD19^＋CD23^＋-cloning hyperplasia in B-CLL .